The 161 in 1 cart for NEO GEO cabs requires a NEO GEO motherboard to run. 

This is an MVS cart, not an AES cart.  The main goal of this board was to create a simple and cost effective board that combined many of the very popular Neo Geo Games. 

This board will not work with other games in a multislot (better put, it will work and not allow the other games to work) and may need bios adjustments in a multislot. But who needs a 4 multi slot when you have 161 games on one board.